David Sinclair – Lifespan (book review)

February 4, 2021

Tom Xants recommended me this book [1] by a leading researcher in gerontology and top dog of an Harvard anti-ageing research centre. That got me curious but before taking anyone’s advice seriously, I follow the Krauser Rule Of Data Sourcing, namely I google a picture of him to check out his physiognomy. Krauser don’t take no advice from dorks, fags, or pedo-faced bugmen. Judge for yourself.

From the set of Little Britain

He’s over 50 and this is an anti-ageing book so I think we can all agree Dr Sinclair passes the first smell test. I paid Kindle my £4.99 and dived into the 473-page text. What did I learn?

The book is split into three sections: past, present, and future. The past is by far the best as it focuses entirely on Sinclair’s official area of expertise, the scientific literature of ageing. He’s a legit top-tier expert in this field. He gives an outline of the health problems caused by ageing and the existing published research on fighting it (mostly in mice). His central theme is that ageing is a disease and there is no biological necessity for it. He considers various scientific explanations for the ageing mechanism and dismisses most as dealing with the downstream effects of ageing rather than the core process.

What’s the core process, Krauser?

Unwanted side-effects of the DNA repair process, that’s what. Sinclair says almost all lifeforms, including those as simple as yeast, have a survival circuit that flips between two states. Normally, the circuit is engaged in processes aiding reproduction including literal cell division and growth. There are enzymes called Sirtains that direct this process and everything is happy as Larry in good times. However, our DNA comes under daily assault by the forces of the earth causing damage to literally trillions of cells. The assault can be cosmic rays, UV light, X-rays, waste products from metabolization of food, viruses and whatnot. The point is, it’s totally normal, widespread, constant and thus every organism has evolved a survival circuit to clean up the damage. Thus your sirtains (especially sirtain 2) leave their posts doing the daily business of living and act as firefighters on your cells’ DNA, fixing it.

This stuff is BAD for you

Eventually, the damage is too great to be fully repaired or the job takes so long that your sirtains end up neglecting their daily tasks in the rest of the cell. Accumulated damage expresses itself as an unravelling of the DNA loops, causing the nucleus of the cell to get ragged and diffuse. The information contained by the epigenome is thus lost. Sinclair calls this the Information Theory Of Ageing.

All that nasty stuff that happens as we age- grey hair, wrinkles, slow repair, inflexibility, shitting yourself, cancer etc- are symptoms of this condition. If you can find ways to reduce the severity of daily damage, and/or improve sirtain’s ability to repair it, you can delay and possibly even reverse ageing.

This theory leads to some very obvious lifestyle recommendations, especially to reduce the daily damage to your DNA: don’t smoke, don’t booze, don’t catch diseases, don’t get fat, don’t eat junk [2]. There are additional things you can do to boost your sirtain production and clean out senescent (dead/zombie) cells, such as supplementation with quercetin, resveratrol, and NMN. Sinclair also recommends regularly exposing your body to minor stresses so that the survival circuit does regular small repairs to DNA rather than infrequent big jobs. So, intermittent fasting, regular exercise, and hot/cold exposure therapy.

Dude in the glasses was 50 when Cocoon was filmed

That’s the Past section and I found it fascinating. The Present section explores ongoing research and most-likely theoretical advances taking advantage of Sinclair’s position to be strategically located within the scientific community currently researching new therapies. He’s exceedingly optimistic but cautions that none of this research is published or long-term tested on humans. Thus it’s less robust than his Past section but gives ideas to enterprising anti-ageing fans.

The thrust of this section is that we’ll soon have some synthetic compounds, probably daily pills, that specifically address ageing. Work is ongoing to ascertain how to refresh sirtain production (which falls over time), or to splice in repair genes, or lengthen telomere and so on. He foresees a world in which we all wear sophisticated smart watches that constantly test our sweat, blood, heart rate and so on, forwarding the data to advanced computing for real-time detection of infections, poor bio-markers etc. This doesn’t seem at all far fetched to me. He explains how many age-related diseases such as cancer, Alzheimer’s and heart disease can be detected years before they become symptomatic. Catching them early means treating them early.

There’s also some Frankenstein stuff like genetically modifying pigs to grow organs for human transplants and 3D printers for organs [3]. Fascinating.

I made a mistake in my NMN dosage

The last section, Future, can be completely ignored. Now he makes the same mistake 99% of scientists make when writing popular science books: he lectures us all on social and political concerns that he knows less about than the average Twitter blue check. There’s some epic faggotry in this and its a real slog with literally nothing of value worth finding. Skip it.

Finally, in the conclusion, he gets around to the bit I wanted to read all along: what is his protocol? What shit are he and his family taking to keep themselves alive longer. I’ll save you the bother and tell you right now:

  1. One gram of NMN, one gram of resveratol, one gram of metformin every morning;
  2. Daily dose of vitamin D, vitamin K2, and 83mg aspirin;
  3. Low sugar, bread, pasta [4];
  4. Skip one meal a day- basically a gay-ass intermittent fast;
  5. Daily steps;
  6. Gym on weekends, again a gay-ass regime of something that he should do more;
  7. Blood tests every few months to check bio-markers;
  8. Meat on gym days but not otherwise;
  9. No smoking. Avoid microwaved plastic, UV exposure, X-rays, CT scans;
  10. Stay in the shade during the day and cool in bed;
  11. BMI in the healthy range which for him is 23 to 25

I’m glad I read this book because it gives a solid science-backed opinion on what causes ageing and what has been proven to work to stop it [5]. Reading between the lines it gives clear advice on how to design your own anti-ageing protocol. Well done, David.

He’ll probably live longer than me but he certainly won’t be shagging as many hot bitches. If you don’t want to live forever but you do wanna pick up the skirt, buy Daygame Overkill here for just $199. That’s less than $1 a year over your artificially-extended lifespan.

Don’t kid yourself. You want this more than another ten years

[1] Which is about as ironic as Keith Richards recommending me a book on asceticism.
[2] Sorry Tom.
[3] China has a better idea of just throwing the Muslims in concentration camps and using theirs.
[4] I’m on a high-carb bulk right now so I’m breaking this big time but my usual diet matches this advice. I’ll be back on it in a couple of months.
[5] In yeast, mice, and worms.


  1. Great summary. I read the book and was basically scanning for recommendations and practices as a takeaway and did not bother reading the future section at all.

    Btw, I think it should read sirtuins not sirtains.

  2. Half way true the book nice summary

  3. What is the hate on carbs based on? Two places in the world where people live long have a high carb diet; Okinawa and Meditteranean diet.

    • A reasons but top three off my head:
      1) drop carbs and drop water weight: makes it seem like the diet works better
      2) foods high in sugar are normally trigger foods which make people binge. They’re conflating dropping carbs with dropping trigger foods (the binges of which lead to caloric surplus)
      3) it’s the cool new thing

      And just to put that in perspective I used to think the same thing.

      • And not all carbs are created equal. Sugar is particularly bad for long-term health. Those glucose-fructose chains in sugar are metabolized in such a way as to have compounding negative effects. As far as I can find legitimate research, the same can’t be said for other carbs (whether it be simple or complex).

        The Case Against Sugar goes into the research (and the politics, history and economics) of it.

  4. he was on rogan

    BTW nick your style of using footnote numbers is incredibly annoying to the reader. why not just use ()

  5. I’m 47 so we’re about the same age. I’ve always tried to maintain a life of health and fitness despite working a stressful job (elementary school teacher). I’ve earmarked that book to read but I disagree with some of his recommendations from training others and maintaining my own youth.

    I’d def keep meat in as the mainstay of my diet. I’m pretty much pure carnivore most of the time and that shit regrew my hair (can show pics), keeps me effortlessly ripped (it’s not even a challenge) and I’m as strong and muscular as I’ve ever been.

    Your blog and writings have always helped.me.out to no measure. I’m ordering your books, but if you ever want to chat about diet or training, let me know and I’d be all to happy to help out (no catch, free) [Thanks pal. You’re certainly in great shape and looking younger than 47. K.]

    Some recent pics




      • No,. but I want to start. My journey started late in life, but I had 7 years of awesome success on tinder that I felt I didn’t need it. I also felt that people in the last 5 years have become less accepting to random street approaches. The whole game equation has changed dramatically now it seems. Online dating is an absolute dumpster fire and girls are no longer experimental in its novelty like they once were. I’m gonna buy all Nick’s books once work starts again so I can get into it.

      • Describe your tinder lays and stories please, where did you use tinder?? and what countries are the best ??

    • Can you show the hair regrow? How long after carnivore did it starting to happen?

    • Just curious, how long have you been working out / what age did you start?

    • Shawn, elementary school teacher is _not_ a comparatively stressful job. You have regular hours, indoors, with summer vacations and winter breaks, job security, and benefits. You don’t hire or fire anyone. Think about the Principal, who is responsible for the entire school. Think about the Superintendent, who is responsible for the system. Think about the Mayor who needs good schools and teacher votes to get reelected, without raising taxes. Think about air traffic controllers, health care workers, police, and technology workers on deadlines.

      Teaching is an important job, and we need more male teachers as role models for boys. But it ain’t stressful. [Lol. Agreed. K.]

    • Now let’s address the 2 elephants in the room here. First one, are you natural? To me you don’t look natural. You’re carrying a lot of mass while being pretty lean. Second elephant in the room, you say “I’m pretty much pure carnivore most of the time and that shit regrew my hair”. I’ll quote the famous Carl Sagan: “Extraordinary claims require extraordinary evidence.” I call bullshit on that one. You probably started using finasteride (and minoxidil).

      • Yep, Shawn you haven’t addressed Konsti’s question; What PED’s have you used?
        I’m guessing you’re on a TRT regimen?
        Them boulder shoulders look like a cycle or two of Trenbolone to me.
        No hate, just curious.

    • Shawn, Krauser no longer sells his coauthored beginner book. But I have seen it on the web. There are also Youtube videos on the London Daygame Model to prepare you for Nick’s advanced books.
      Also, day game requires certain types of venues. A preview of Nick’s books could help you scout places.

      You have a distinctive and potentially polarizing physique that can attract women for quick hookups. You should do well in gyms, at the beach, etc. Try experimenting with nonthreatening attire, pink, pastel, etc., and contrast the results with Krauser’s rock and roll outlaw look.

      • KL – interesting for you to say it’s not stressful when you don’t know the socioeconomic area or demographic I work for. Regular violence towards staff and other students. More crowd control than actual educating. I don’t get paid vacations nor summers off. I also work night jobs and train on the side. Sure, I’ve done the Krauser period of life where I worked the cushy gravy train of Eikawa and elementary schools in Japan, which is why he probably LOL’s with absolutely zero clue with what he’s LOLing about.

      • Shawn, you wrote “I also work night jobs and train on the side.” Training is a hobby. My hobbies are eating junk food and playing World of Warcraft. It is very stressful to slay dragons and fight orcs on my computer. But I don’t complain that it compounds the stress of my job!

        With your physique, I think you can adequately defend yourself from elementary school students. LOL. Good luck. [Let’s keep this civil. K.]

      • KL, if Shawn finds his job stressful, he finds it stressful. What’s the point of trying to prove him wrong? What’s the point of contradicting his subjective experience?

        Your proposition that “elementary school teacher is _not_ a comparatively stressful job” is based on what? Is it just your opinion? Or is it based on data? From what I know elementary school teacher *is* a stressful job with high rates of burnout. But that’s just an impression. That’s why I did a quick google search. This is what I found: https://notwaitingforsuperman.org/teacher-burnout-statistics/

        Here’s a quote from another link: “For example, elementary school teachers are consistently found to be more stressed than secondary school teachers; a recent study done by the University of Missouri found that 93% of elementary school teachers reported high stress levels.” Source: https://www.thegraidenetwork.com/blog-all/2018/8/1/crayons-and-cortisol-the-epidemic-of-teacher-stress

      • @Konsti Yes, any job can be stressful if you have a bad boss or bad fit.

        I have extensive experience as a professional educator. Teaching has high burnout because many aspiring teachers lack competitive degrees or demanding professional experience. “Conclusion 1: Teachers just beginning in the profession will be surprised at the level of commitment which the job requires.”

        This is relevant because there is denial in the Manosphere, and pervasive lack of awareness. Shawn raises red flags by saying his job is stressful or dangerous, and not anticipating skepticism about his extraordinary muscle and hair growth. Obviously hair and muscles are not impeding his love life, and Shawn might be obsessing over irrelevant trivialities. Anabolic and hair loss drugs have notorious sexual side effects. Or maybe Shawn uses job and training as excuses to avoid the social anxiety of meeting women. I needled Shawn about his job to give realistic perspective. Some guys succeed despite being shorter, skinnier, balder, with tougher jobs. Those guys focus on things that matter, and don’t feel limited.

      • @DL, what is your point exactly? Your reply is incoherent, all over the place and full of red herrings. Almost every single sentence in your last reply can be refuted/debunked. Yes, it’s that bad.

        Let me reiterate my points:

        1. I think Shawn is not natural. I think he’s using steroids. My degree of certainty is 75%. I have no smoking gun, however there are a few red flags like his age, mass and leanness.

        2. Shawn claims “’I’m pretty much pure carnivore most of the time and that shit regrew my hair (can show pics)”. I call bullshit and ask for evidence for this extraordinary claim. I don’t believe the carnivore diet regrew his hair. I think he’s on some hair regrowth protocol like finasteride, dutasteride, minoxidil and/or something else that’s clinically proven to work against hair loss. What I suppose is that he’s on the carnivore diet AND on finasteride (and eventually minoxidil) and that for some bizarre ego gratification reason he attributes his hair regrowth on the carnivore diet. But this is pure speculation of course.

        3. Shawn claims “despite working a stressful job (elementary school teacher)”. I believe him totally. I don’t see the point of contradicting his subjective experience. If Shawn claims “I am a elementary school teacher and I find it stressful” and you, DL, claim “I am an elementary school teacher and I find it very relaxing” I would believe both of you, because we’re talking about subjective experience here. Two people can experience the same conditions differently. You claim “elementary school teacher is _not_ a comparatively stressful job”. I do not agree with that claim and I gave you some counterevidence. Now, to be totally clear and coherent, there’s a difference between finding a job stressful and saying a job IS (or is not) stressful.

        Again, what is your point exactly? [I think you’re all being a bit hard on Shawn. He posted photos and told you some of his protocol. Fair enough if you don’t believe him and wish to challenge it but keep it civil. This comment is pretty civil, imo. K.]

    • @Konsti: Yes, it is suspicious that diet causes muscle and hair growth, instead of drugs.

      Exaggerating stress and violence of teaching is mawkish. Ignoring the drug suspicion compounds Shawn’s exhibition of social insensitivity.

      Especially for online dating, social awareness is more important than extreme muscles or hair. Women are anxious about meeting strangers during a pandemic.

      Shawn, your Tinder profile should say that you enjoy a safe, healthy lifestyle, looking for a safe lockdown partner or Covid-snuggle-bunny. Address the Covid elephant in the room! You already display muscles. But some might find you to be an intimidating, hairy beast, or a vain, self-absorbed bodybuilder. Try a kind, gentle picture that makes you approachable and relatable, with a pet, or kids, with a smile, and no glasses.

  6. Good stuff, thanks for sharing/summarizing Krauser

  7. If anyone can find a competitive price on bulk nmn, drop the link here. At 1gram a day the cheapest I found was 250pounds for 100grams. 2 pound 50 a day which would be considered high price tag for a daily supplement.

  8. Nice review. Andrew Steele also has a book out on if and when the coming anti aging revolution will happen (his view is that there will be a senolytic drug in the next 10 years probably):


    • Thanks a bunch for this link!

      But 1 thing wasn’t explained: daily dose of aspirin?? Can anyone tell me what it’s for?..

      • @PrinceofPersia To prevent strokes – after age 45, everybody should probably take low dose 75mg Aspirin (excepting those with previous gastrointestinal bleeds).

  9. Krauser you need to check out the book We Want to Live by Aajonus Vonderplanitz.

    It’s completely different than anything you’ve read and his work has greatly turned around my health.

    Very quickly he advocates a raw food diet based around raw meat, raw milk and fresh vegetable juices.

    He rejects the mainstream belief around germ theory, viruses and says the main cause of disease isn’t bacteria, but rather toxins.

    The diet is called the Primal diet.

  10. David Sinclair talked extensively in his latest podcast about the various treatments currently available to reverse cosmetic signs of aging.

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